The 5 Best Milk Thistle Supplements

Milk thistle has been used as a liver tonic for centuries and is becoming increasingly popular among people who are looking to improve liver health. Not only is it known to protect the liver from damage, but evidence suggests milk thistle can also reduce inflammation and cholesterol levels.

To ensure you're buying herbal supplements of the highest quality, I've rounded up five of the most potent milk thistle supplements on the market. You'll be getting high-quality ingredients in each one of these products that have been specially formulated to help you take control of your health.

If you're struggling with health problems or just looking to support your liver, you may consider taking a milk thistle supplement. This article will cover the five best options, their benefits, and potential side effects.


My Selection Process

Searching for the perfect milk thistle supplement can be overwhelming. To help you get started, I have done extensive research and carefully selected a variety of options to ensure they meet my high standards.

All supplements are tested rigorously for ingredient potency as well as contaminants like heavy metals and microbes. Only the best milk thistle supplements with proven safety and effectiveness made it into this article. I hope this makes your decision easier than ever before. Keep reading to discover the best milk thistle supplement!


Thorne Siliphos Milk Thistle Phytosome

Best for antioxidant and liver support.

Why I Dig It

Thorne's milk thistle phytosome provides all the benefits of 180 mg of Silybin marianum extract per serving. This milk thistle supplement contains antioxidant properties that can strengthen liver cell membranes, protect liver cells from free radical damage, and help maintain the liver's antioxidant system. Also, this supplement can protect against damage from ethanol, acetaminophen, and automobile exhaust. Air pollutants aren't just bad for your lungs; they can hurt your liver too.

Plus, Thorne boasts superior absorption compared to other conventional milk thistle products. Thorne uses phytosome technology, a patented form of the milk thistle flavonoid silybin, allowing for superior absorption.

With every product backed by research and made without gluten, dairy, or soy, you know Thorne won't let you down. As always, Thorne is one of my top picks!

The Data Dump

Thorne's supplements are among the highest quality supplements available today. Thorne goes to great lengths to ensure each capsule contains only pure ingredients without hidden or potentially harmful additives. They perform four rounds of independent testing at all stages of production. They use third-party labs to examine each product for identity, stability, purity, potency, microbial contaminants, pesticide residues, and heavy metals.

Thorne is in compliance with Current Good Manufacturing Practice (cGMP) standards set by the FDA. In addition, Throne is NSF sport certified which is a program that certifies that what is on the label is in the package and that the product does not contain unsafe levels of contaminants, masking agents, or prohibited substances.

Throne does not currently release Certificates of Analysis (CoA) for its products. However, be on the lookout as they are getting CoA's published on their website, which will likely happen in 2023! This rigorous testing set them apart from other companies, making Thorne one of the most trusted products and offering one of the best milk thistle supplements.


Pure Synergy SuperPure Organic Milk Thistle Extract

Best for supporting healthy liver function.

Why I Dig It

Pure Synergy's organic milk thistle is packed with 375 mg of pure milk thistle extract per serving. This supplement supports healthy liver function, antioxidant protection, and detoxification. Plus, it's also vegan, gluten-free, non-GMO, and kosher.

The Data Dump

With Pure Synergy you can rest assured that you're getting highest quality ingredients with every batch. As part of this commitment to providing safe and effective products, they undergo rigorous third-party testing for heavy metals, microbes, pesticides, solvent residues, gluten, and vitamins and minerals.

Every stage of production is tested up to four separate times – raw material, during blending, when it's encapsulated, and then again once it's a finished product. You can see each Certificate of Compliance (aka Certificate of Analysis) for each product. This document verifies the results of the final testing.

Pure Synergy follows industry-leading standards regarding quality control at every stage of production. This is a great brand and one I have used and trusted for many years.


Gaia Herbs Milk Thistle Seed

Best high potency blend to maintain healthy liver function.

Why I Dig It

Gaia Herbs milk thistle extract can help you maintain optimal liver function for long-term well-being. This organic and vegan supplement is made in the United States using a highly concentrated formula of 600 mg of milk thistle seed extract and 270 mg of silymarins. Also, it is dairy-free, gluten-free, and soy-free.

Gaia's extraction process helps to preserve the potency of this vital nutrient, unlocking its many benefits. Taking this daily can help support healthy liver function, allowing you to get back to feeling your best.

The Data Dump

Gaia Herbs is dedicated to delivering nutritional supplements of the highest quality. They test every product for microbes, heavy metals, and pesticides, so you can rest assured that you're consuming a plant-based health supplement that meets stringent quality standards. Also, all of Gaia’s production facilities are FDA-inspected.

Their Certificates of Analysis are readily available online so you can view firsthand the results of each test. Enjoy all the benefits of this milk thistle extract while feeling confident in your purchase due to Gaia's deep commitment to quality assurance.


Pure Encapsulations Silymarin Milk Thistle Extract

Best for antioxidant protection and liver support.

Why I Dig It

Pure Encapsulations milk thistle extract is a potent supplement for supporting liver function and antioxidant protection. This milk thistle supplement is made from Silybum marianum and one capsule offers 350 mg. Plus, it's standardized to contain 80% silymarin, making it incredibly concentrated.

These capsules are free from allergies like gluten, tree nuts, peanuts, GMOs, artificial colors and sweeteners, artificial flavors, shellacs, and unnecessary binders and preservatives.

The Data Dump

Pure Encapsulations only sources ingredients from trusted suppliers. They also conduct research and clinical trials to ensure the safety and effectiveness of the product. This company is an excellent option for anyone seeking high-quality supplements free from common allergens.

All supplements are carefully manufactured by Current Good Manufacturing Practice (cGMP) standards and tested at independent laboratories to guarantee maximum potency and purity. To further reduce its environmental footprint, Pure Encapsulations has partnered with TerraCycle where you can quickly ship your empty packaging back to TerraCycle for recycling.


Metabolic Maintenance Silymarin Milk Thistle Extract

Best for liver cleanse and detox. 

Why I Dig It

Metabolic Maintenance's milk thistle supplement is a great choice. This excellent supplement ensures your liver gets the support it needs. The silymarin complex helps stabilize cell membranes in the liver, making sure it's kept in tip-top shape. This milk thistle extract is standardized to 80% silymarin content, delivering 300 mg of premium quality silymarin.

This vegetarian capsule has no fillers, binders, preservatives, artificial colors, or flavors. It does not contain wheat (gluten), eggs, milk, soybeans, fish, shellfish, peanuts, or tree nuts. To top things off, the supplement arrives in BPA-free amber glass bottles that protect from light contamination.

The Data Dump

Metabolic Maintenance's supplements are one's you can trust since all ingredients are third-party tested for quality and purity as well as heavy metals and microbes. Metabolic Maintenance goes above and beyond by sourcing its raw materials ethically and ensuring they meet every one of its standards before reaching you.

Also, all supplements are produced according to Current Good Manufacturing Practice standards (cGMP). I am a fan of this company and currently use some of their herbal supplements.


Benefits of Milk Thistle


For millennia, people have recognized the healing properties of milk thistle. This ancient plant, scientifically known as Silybum marianum, is native to Europe but can also be found in parts of the United States and South America.

In the Middle Ages, milk thistle was used as an antidote to liver toxins. Eclectic physicians Felter and Lloyd recorded its usefulness against "congestion" of the liver and kidney in 1898, while Native Americans applied it to treat boils and other skin diseases. Homeopathic doctors have used milk thistle seeds to address illnesses such as gallstones, jaundice, and liver dysfunction.

Taking milk thistle supplements can be immensely beneficial for your health, particularly when it comes to liver protection. Multiple studies show considerable improvements in various aspects of liver function. By incorporating this natural remedy into their diet, individuals with illnesses like hepatitis and non-alcoholic fatty liver disease have reported reduced inflammation and damage.

Milk thistle has been studied extensively for its potential health benefits due to its antioxidant and anti-inflammatory properties. Here are some of the benefits of taking milk thistle:

Liver Support

Milk thistle is primarily used as a natural remedy to protect from liver damage caused by alcohol or toxins such as drugs, industrial chemicals, pesticides, and acetaminophen (Tylenol). Studies have shown that it can reduce inflammation in liver cells while also promoting cellular repair, which maintains healthy liver function. Milk thistle also helps with various liver diseases, such as liver cirrhosis and hepatitis C.

Neuroprotective Effects

Milk thistle is emerging as a powerful ally in the fight against many neurological conditions like Alzheimer's, Parkinson's, and even cerebral ischemia. Its anti-inflammatory and antioxidant qualities make it beneficial for brain health; milk thistle has been proven effective at reversing cognitive impairment associated with aging - an exciting breakthrough!

Improves Heart Health

The active compounds in milk thistle have been linked with improved cholesterol levels, triglycerides, blood pressure, and other markers associated with heart disease. Additionally, clinical studies indicate milk thistle can have anti-obesity effects through reduced fat accumulation and antioxidant and anti-inflammatory pathways.

Diabetes Treatment

Milk thistle may help treat type 2 diabetes by lowering fasting glucose levels and significantly reducing hemoglobin A1C (HbA1c), which measures your average blood sugar levels over the past 3 months. The HbA1c test is commonly used to diagnose prediabetes and diabetes.

Overall, milk thistle could confer multiple health benefits—from enhanced liver health protection to treating those suffering from diabetes. Adding this powerful herbal tonic alongside specific lifestyle adjustments could have potent health benefits.


Milk Thistle FAQs


Whether you want to discover the benefits of milk thistle or understand potential side effects, I've taken a deep dive into all there is to know about this powerful herb. This way you can make an informed choice for your health without leaving any questions unanswered!

  • This depends on your individual needs and preferences. Generally speaking, extracts made into a capsule form are considered the most potent forms of milk thistle since they contain concentrated amounts of the active ingredient silymarin. In particular, look for an extract with at least 70-80% silymarin to maximize its effectiveness.

    If you're looking for something that is budget friendly, you can get milk thistle powder instead, but make sure it's certified organic and contains no fillers or additives. You can also buy liquid forms of milk thistle if convenience is important; these typically come in tincture form with a recommended dosage on the label.

    Always ensure the product comes from a reputable company. Please read the label and make sure it does not include artificial ingredients. Check for third-party testing and companies that follow Current Good Manufacturing Practice (CGMP) regulations. You can also look for brands offering organic milk thistle, but this depends on personal preference.

  • The recommended daily milk thistle dose varies based on scientific evidence and depends on your current health status. Generally it is considered safe to take up to 500 mg of milk thistle extract daily, but this should be divided up into several doses. For those with hepatitis C, studies have shown that higher doses (up to 630 mg per day) were beneficial. In another study, patients took 600 mg of milk thistle per day for 12 months. Researchers concluded that this treatment helped improve insulin resistance in patients with diabetes.

  • Generally speaking, milk thistle is a safe and effective herbal supplement for most people. However, some individuals should avoid taking milk thistle due to potential allergies or interactions with other medications.

    People should avoid milk thistle if allergic to ragweed, daisies, chrysanthemums, marigold, or any plant in the same family (Asteraceae/Compositae). Milk thistle may interact with certain medications. Therefore, it is essential to speak with a physician before adding this supplement to your regimen.

  • Yes, taking milk thistle every day is generally accepted as safe. Milk thistle has been widely studied for its medicinal benefits. It is commonly used to treat various ailments, such as liver disease, high cholesterol, diabetes, chronic kidney disease, and certain types of cancer. Milk thistle is an effective treatment for these conditions because it reduces inflammation and promotes antioxidant activity.

  • Most research studies divide milk thistle into two or three doses daily. One study had patients take the milk thistle supplement in three separate doses (one 200 mg dose three times a day). Similarly, others examining patients with liver cirrhosis had subjects take a 150 mg dose three times per day (equating to 450 mg per day).

  • Milk thistle is renowned for its safety even when consumed in high doses. However, the most commonly reported side effects are headaches and uncomfortable itchiness of the skin, with a lesser chance of gastrointestinal upset like nausea or diarrhea.

  • Yes, milk thistle can help detox your body. This herb has been used for centuries as a natural detoxifier and is known for its liver-cleansing properties. Milk thistle aids in detoxification by helping to remove toxins from the liver and promoting healthy liver function. Additionally, milk thistle is a powerful antioxidant that helps to protect the liver from damage.

  • A few different vitamins can help repair the liver and offer positive liver protecting benefits. Vitamin A is important for cell growth; it can help the liver regenerate itself. Vitamin C is a potent antioxidant that can help protect the liver from damage. Lastly, vitamin E, another antioxidant, can help reduce inflammation in the liver.

  • Studies suggest that milk thistle may have beneficial effects on the kidneys. A study from 2008 found that milk thistle was effective at protecting the kidneys from renal ischemia and may provide a novel strategy for humans suffering from acute kidney failure. Also, it may protect kidney cells from the toxic effects of chemotherapy.

  • When it comes to supporting and repairing the liver, a wide variety of foods are beneficial. Here are some key foods that support liver health:

    1. Cruciferous vegetables – broccoli, cauliflower, kale, and cabbage are powerful antioxidants. Additionally, these veggies provide generous amounts of vitamins A, B6, and K and minerals like magnesium and potassium for liver support.

    2. Avocados – a superfood rich in healthy fats that can help the body detoxify from heavy metals or other contaminants while protecting your liver cells against oxidative damage due to its antioxidant effects.

    3. Herbs & spices – many herbs and spices like turmeric have powerful anti-inflammatory properties.

    4. Berries - certain berries, such as blueberries and mulberries, have been shown to help fight against liver cancer due to their high levels of antioxidants.

    5. Beets – loaded with powerful antioxidants! Studies show that regular consumption of cooked, raw, or even juiced beets can help protect against liver disease and other health issues related to oxidative stress.

    Maintaining good nutrition habits focused on nutrient-dense plant-based options will always benefit our body, including our liver!

The Recap

Whether you're setting a course for natural liver health or just curious, I've got the scoop! Check out my collection of the best milk thistle supplements. Get ready to make an informed decision and feel great about it.


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